Split hand/foot malformations with microdeletions at chromosomes 7 and 19 detected using array comparative genomic hybridization.

  title={Split hand/foot malformations with microdeletions at chromosomes 7 and 19 detected using array comparative genomic hybridization.},
  author={Chin-Jui Wu and Y. Su and Tzu-Hung Lin and L. Tseng and K. Chao},
  journal={Taiwanese journal of obstetrics & gynecology},
  volume={54 1},
The split hand/split foot malformation (SHFM), which is also known as ectrodactyly, is a limb malformation syndrome involving the central rays of the hand or foot. The typical SHFM may present with syndactyly; median clefts of the hands and feet; and aplasia or hypoplasia (or both) of the phalanges, metacarpals, and metatarsals. Numerous human gene defects can cause SHFMs. For example, the SHFM1 gene is associated with deletions of varying extent on chromosome 7q21eq22 [1], whereas SHFM2 is… Expand
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