Split ends antagonizes the Notch and potentiates the EGFR signaling pathways during Drosophila eye development

@article{Doroquez2007SplitEA,
  title={Split ends antagonizes the Notch and potentiates the EGFR signaling pathways during Drosophila eye development},
  author={David B. Doroquez and Terry L Orr-Weaver and Ilaria Rebay},
  journal={Mechanisms of Development},
  year={2007},
  volume={124},
  pages={792-806}
}
The Notch and Epidermal Growth Factor Receptor (EGFR) signaling pathways interact cooperatively and antagonistically to regulate many aspects of Drosophila development, including the eye. How output from these two signaling networks is fine-tuned to achieve the precise balance needed for specific inductive interactions and patterning events remains an open and important question. Previously, we reported that the gene split ends (spen) functions within or parallel to the EGFR pathway during… CONTINUE READING

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spenito is required for sex determination in Drosophila melanogaster.

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