Split-course versus continuous thoracic radiation therapy for limited-stage small-cell lung cancer: final report of a randomized phase III trial.

@article{Blackstock2005SplitcourseVC,
  title={Split-course versus continuous thoracic radiation therapy for limited-stage small-cell lung cancer: final report of a randomized phase III trial.},
  author={Arthur William Blackstock and Jeffery A Bogart and Charles M. Matthews and James F Lovato and Thomas McCoy and Kim Livengood and Coty P H Ho and Douglas F White and James Norman Atkins and Antonius A. Miller},
  journal={Clinical lung cancer},
  year={2005},
  volume={6 5},
  pages={287-92}
}
The optimal integration of radiation and chemotherapy for limited-stage small-cell lung cancer (SCLC) remains unclear. This phase III trial was conducted to determine whether chemotherapy plus interdigitating split-course thoracic radiation therapy (RT) improved survival compared with standard-dose continuous thoracic RT. One hundred fourteen patients were randomized to receive 50 Gy thoracic RT delivered in 2.0-Gy fractions given continuously (5 weeks) concurrent with the first 2 cycles of… CONTINUE READING