Split GFP complementation assay for quantitative measurement of tau aggregation in situ.

@article{Chun2011SplitGC,
  title={Split GFP complementation assay for quantitative measurement of tau aggregation in situ.},
  author={Wanjoo Chun and Geoffrey Waldo and Gail V W Johnson},
  journal={Methods in molecular biology},
  year={2011},
  volume={670},
  pages={109-23}
}
A primary pathological hallmark of Alzheimer disease brain is the presence of neurofibrillary tangles, which are highly aggregated and insoluble accumulations of the microtubule-associated protein tau. Although it is becoming increasingly apparent that the mature neurofibrillary tangles are not the toxic species, intermediates between soluble tau and the neurofibrillary tangles likely play key roles in the neurodegenerative process. Therefore, it is critically important to be able to… CONTINUE READING