Splicing regulator SC35 is essential for genomic stability and cell proliferation during mammalian organogenesis.

@article{Xiao2007SplicingRS,
  title={Splicing regulator SC35 is essential for genomic stability and cell proliferation during mammalian organogenesis.},
  author={Ran Xiao and Ye Sun and J Ding and Shengrong Lin and Dave W Rose and Michael G. Rosenfeld and Xiang-Dong Fu and Xue Li},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 15},
  pages={5393-402}
}
The members of the SR family of splicing regulators were initially characterized for their critical roles in constitutive and regulated splicing. They are implicated in different aspects of gene expression processes, including transcription, RNA stability, mRNA transport, and translational control. While knockout studies have demonstrated their essential functions during animal development, the pathway(s) leading to a specific cellular phenotype remains poorly understood. We report here that… CONTINUE READING