Splicing promotes the nuclear export of β-globin mRNA by overcoming nuclear retention elements.

@article{Akef2015SplicingPT,
  title={Splicing promotes the nuclear export of $\beta$-globin mRNA by overcoming nuclear retention elements.},
  author={Abdalla Akef and Eliza S. Lee and Alexander F. Palazzo},
  journal={RNA},
  year={2015},
  volume={21 11},
  pages={
          1908-20
        }
}
Most current models of mRNA nuclear export in vertebrate cells assume that an mRNA must have specialized signals in order to be exported from the nucleus. Under such a scenario, mRNAs that lack these specialized signals would be shunted into a default pathway where they are retained in the nucleus and eventually degraded. These ideas were based on the selective use of model mRNA reporters. For example, it has been shown that splicing promotes the nuclear export of certain model mRNAs, such as… 

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