Splicing of U12-type introns deposits an exon junction complex competent to induce nonsense-mediated mRNA decay.

@article{Hirose2004SplicingOU,
  title={Splicing of U12-type introns deposits an exon junction complex competent to induce nonsense-mediated mRNA decay.},
  author={Tetsuro Hirose and Mei-Di Shu and J. A. Steitz},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 52},
  pages={17976-81}
}
Metazoan cells have two pathways for intron removal involving the U2- and U12-type spliceosomes, which contain mostly nonoverlapping sets of small nuclear ribonucleoproteins. We show that in vitro splicing of a U12-type intron assembles an exon junction complex (EJC) that is comparably positioned and contains many of the same components as that deposited by… CONTINUE READING