Splicing of Balbiani ring 1 gene pre-mRNA occurs simultaneously with transcription

@article{Baurn1994SplicingOB,
  title={Splicing of Balbiani ring 1 gene pre-mRNA occurs simultaneously with transcription},
  author={G{\"o}ran Baur{\'e}n and Lars Wieslander},
  journal={Cell},
  year={1994},
  volume={76},
  pages={183-192}
}
The 40 kb Balbiani ring 1 (BR1) gene is at a given moment transcribed by, on average, 120 RNA polymerases. Here we directly assay the excision of introns both in the nascent and in the released nucleoplasmic BR1 pre-mRNAs, isolated by microdissection. We show that intron 3, located 3 kb from the 5' end of the pre-mRNA, is excised simultaneous with transcription. Within 2.5 min of transcription time, 50% of the pre-mRNA molecules have lost the intron. Intron 4, located 600 bases from the… CONTINUE READING
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