Splicing is required for rapid and efficient mRNA export in metazoans.

@article{Luo1999SplicingIR,
  title={Splicing is required for rapid and efficient mRNA export in metazoans.},
  author={Ming-juan Luo and Robin F Reed},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1999},
  volume={96 26},
  pages={14937-42}
}
Pre-mRNA splicing is among the last known nuclear events before export of mature mRNA to the cytoplasm. At present, it is not known whether splicing and mRNA export are biochemically coupled processes. In this study, we have injected pre-mRNAs containing a single intron or the same mRNAs lacking an intron (Deltai-mRNAs) into Xenopus oocyte nuclei. We find that the spliced mRNAs are exported much more rapidly and efficiently than the identical Deltai-mRNAs. Moreover, competition studies using… CONTINUE READING

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The spliced mRNP assembled in vitro targets mRNA for export

  • M. Neville, F. Stutz, L. Lee, L. I. Davis, M. Rosbash
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