Splicing double: insights from the second spliceosome

@article{Patel2003SplicingDI,
  title={Splicing double: insights from the second spliceosome},
  author={Abhijit A. Patel and Joan A. Steitz},
  journal={Nature Reviews Molecular Cell Biology},
  year={2003},
  volume={4},
  pages={960-970}
}
Almost 20 years after the discovery of introns and RNA splicing, a second spliceosome was uncovered. Although this new spliceosome is structurally and functionally analogous to the well-characterized major-class splicing apparatus, it mediates the excision of a minor class of evolutionarily conserved introns that have non-canonical consensus sequences. This unanticipated diversity in the splicing machinery is refining both the mechanistic understanding and evolutionary models of RNA splicing. 

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