Splicing-Dependent RNA Polymerase Pausing in Yeast

  title={Splicing-Dependent RNA Polymerase Pausing in Yeast},
  author={Ross D. Alexander and Steven A. Innocente and J. David Barrass and Jean D. Beggs},
  booktitle={Molecular cell},
In eukaryotic cells, there is evidence for functional coupling between transcription and processing of pre-mRNAs. To better understand this coupling, we performed a high-resolution kinetic analysis of transcription and splicing in budding yeast. This revealed that shortly after induction of transcription, RNA polymerase accumulates transiently around the 3' end of the intron on two reporter genes. This apparent transcriptional pause coincides with splicing factor recruitment and with the first… CONTINUE READING
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