Spliced-leader RNA trans splicing in a chordate, Oikopleura dioica, with a compact genome.

@article{Ganot2004SplicedleaderRT,
  title={Spliced-leader RNA trans splicing in a chordate, Oikopleura dioica, with a compact genome.},
  author={Philippe Ganot and Torben Kalles\oe and Richard Reinhardt and Daniel Chourrout and Eric M. Thompson},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 17},
  pages={7795-805}
}
trans splicing of a spliced-leader RNA (SL RNA) to the 5' ends of mRNAs has been shown to have a limited and sporadic distribution among eukaryotes. Within metazoans, only nematodes are known to process polycistronic pre-mRNAs, produced from operon units of transcription, into mature monocistronic mRNAs via an SL RNA trans-splicing mechanism. Here we demonstrate that a chordate with a highly compact genome, Oikopleura dioica, now joins Caenorhabditis elegans in coupling trans splicing with… CONTINUE READING
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