SpliceTrap: a method to quantify alternative splicing under single cellular conditions

  title={SpliceTrap: a method to quantify alternative splicing under single cellular conditions},
  author={Jie Wu and Martin Akerman and Shuying Sun and W. Richard McCombie and Adrian R. Krainer and Michael Q. Zhang},
  volume={27 21},
MOTIVATION Alternative splicing (AS) is a pre-mRNA maturation process leading to the expression of multiple mRNA variants from the same primary transcript. More than 90% of human genes are expressed via AS. Therefore, quantifying the inclusion level of every exon is crucial for generating accurate transcriptomic maps and studying the regulation of AS. RESULTS Here we introduce SpliceTrap, a method to quantify exon inclusion levels using paired-end RNA-seq data. Unlike other tools, which focus… CONTINUE READING
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