Splice variants of the CaV1.3 L-type calcium channel regulate dendritic spine morphology

@inproceedings{Stanika2016SpliceVO,
  title={Splice variants of the CaV1.3 L-type calcium channel regulate dendritic spine morphology},
  author={Ruslan Iljitsch Stanika and Marta Campiglio and Alexandra Pinggera and Amy Lee and J{\"o}rg Striessnig and Bernhard E Flucher and Gerald J Obermair},
  booktitle={Scientific reports},
  year={2016}
}
Dendritic spines are the postsynaptic compartments of glutamatergic synapses in the brain. Their number and shape are subject to change in synaptic plasticity and neurological disorders including autism spectrum disorders and Parkinson's disease. The L-type calcium channel CaV1.3 constitutes an important calcium entry pathway implicated in the regulation of spine morphology. Here we investigated the importance of full-length CaV1.3L and two C-terminally truncated splice variants (CaV1.342A and… CONTINUE READING