Splice-specific functions of gephyrin in molybdenum cofactor biosynthesis.

  title={Splice-specific functions of gephyrin in molybdenum cofactor biosynthesis.},
  author={Birthe Smolinsky and Sabrina A. Eichler and Sabine Buchmeier and Jochen C Meier and Guenter Schwarz},
  journal={The Journal of biological chemistry},
  volume={283 25},
Gephyrin is a multifunctional protein involved in the clustering of inhibitory neuroreceptors. In addition, gephyrin catalyzes the last step in molybdenum cofactor (Moco) biosynthesis essential for the activities of Mo-dependent enzymes such as sulfite oxidase and xanthine oxidoreductase. Functional complexity and diversity of gephyrin is believed to be regulated by alternative splicing in a tissue-specific manner. Here, we investigated eight gephyrin variants with combinations of seven… CONTINUE READING
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