Splice-site A choice targets plasma-membrane Ca2+-ATPase isoform 2 to hair bundles.

Abstract

Localization of mechanotransduction in sensory hair cells to hair bundles requires selective targeting of essential proteins to specific locations. Isoform 2 of the plasma-membrane Ca2+-ATPase (PMCA2), required for hearing and balance, is found exclusively in hair bundles. We determined the contribution of splicing at the two major splicing sites (A and C… (More)

Topics

9 Figures and Tables