Splice isoforms as therapeutic targets for colorectal cancer.

  title={Splice isoforms as therapeutic targets for colorectal cancer.},
  author={Koh Miura and Wataru Fujibuchi and Michiaki Unno},
  volume={33 12},
Alternative pre-mRNA splicing allows exons of pre-mRNA to be spliced in different arrangements to produce functionally distinct mRNAs. More than 95% of human genes encode splice isoforms, some of which exert antagonistic functions. Recent studies revealed that alterations of the splicing machinery can cause the development of neoplasms, and understanding the splicing machinery is crucial for developing novel therapeutic strategies for malignancies. Colorectal cancer patients need novel… CONTINUE READING
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