Splice Isoforms of the Polyglutamine Disease Protein Ataxin-3 Exhibit Similar Enzymatic yet Different Aggregation Properties

@inproceedings{Harris2010SpliceIO,
  title={Splice Isoforms of the Polyglutamine Disease Protein Ataxin-3 Exhibit Similar Enzymatic yet Different Aggregation Properties},
  author={Ginny Marie Harris and Katerina Dodelzon and Lijie Gong and Pedro Gonzalez-Alegre and Henry L. Paulson},
  booktitle={PloS one},
  year={2010}
}
Protein context clearly influences neurotoxicity in polyglutamine diseases, but the contribution of alternative splicing to this phenomenon has rarely been investigated. Ataxin-3, a deubiquitinating enzyme and the disease protein in SCA3, is alternatively spliced to encode either a C-terminal hydrophobic stretch or a third ubiquitin interacting motif… CONTINUE READING