Splenocytes in early pregnancy promote embryo implantation by regulating endometrial differentiation in mice.

@article{Takabatake1997SplenocytesIE,
  title={Splenocytes in early pregnancy promote embryo implantation by regulating endometrial differentiation in mice.},
  author={Keiko Takabatake and Hiroshi Fujiwara and Yasuo Goto and Takahiro Nakayama and Toshihiro Higuchi and Jun Fujita and Michiyuki Maeda and T. Mori},
  journal={Human reproduction},
  year={1997},
  volume={12 10},
  pages={
          2102-7
        }
}
We have reported that i.v. administration of splenocytes prepared from early pregnant mice promoted embryo implantation in pseudopregnant CD-1 (ICR) (closed colony) mice. In this study, the similar effects of splenocytes were confirmed using an inbred strain, BALB/c mice, and the mechanism was further investigated. Splenocytes were prepared from pregnancy day 4 (P4-spl) and dioestrus mice (Di-spl), and supernatant of P4-spl suspension (P4-sup) was used as controls. On pseudopregnancy day 2… 
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55 Citations

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Citation Type

Administration of thymocytes derived from non-pregnant mice induces an endometrial receptive stage and leukaemia inhibitory factor expression in the uterus.
TLDR
Findings showed that thymocytes, especially CD4-positive lymphocytes, facilitate embryo implantation, probably by regulating endometrial differentiation.
Intrauterine administration of peripheral blood mononuclear cells enhances early development of the pre‐implantation bovine embryo
TLDR
It is suggested that intrauterine administration of PBMCs improves endometrial environment, which promotes early development of pre‐attachment conceptuses and thereby improves the pregnancy rate.
Expression of Ly‐6A/E in the mouse uterus during implantation period
TLDR
It is suggested that Ly‐6A/E plays a role in embryo implantation through its expression in the endometrial cells, which is concurrent with decidualization.
Administration of peripheral blood mononuclear cells into the uterine horn to improve pregnancy rate following bovine embryo transfer.
Human peripheral blood mononuclear cells (PBMC) in early pregnancy promote embryo invasion in vitro: HCG enhances the effects of PBMC.
TLDR
It is indicated that PBMC from pregnant women promoted murine embryo invasion in vitro and this effect of PBMC was enhanced by HCG, suggesting thatPBMC at the implantation site are activated byHCG secreted from the embryo, following which PBMC regulate embryo invasion.
Immune cells contribute to systemic cross-talk between the embryo and mother during early pregnancy in cooperation with the endocrine system
  • H. Fujiwara
  • Biology
    Reproductive medicine and biology
  • 2006
TLDR
It is found that peripheral blood mononuclear cells (PBMC) derived from pregnant women promoted progesterone production by human luteal cells and it is proposed that both hormones and immune cells participate in this systemic crosstalk.
Suppression of natural killer cell activity by splenocyte transplantation in a rat model of endometriosis.
TLDR
It was demonstrated that abnormal immunity caused by allograft of immune cells could recur in an endometriosis rat model.
Intrauterine administration of autologous peripheral blood mononuclear cells promotes implantation rates in patients with repeated failure of IVF-embryo transfer.
TLDR
Intrauterine administration of autologous PBMC may be an effective approach to improve embryo implantation in patients with repeated IVF failures.
Costimulatory Molecule CD28 Participates in the Process of Embryo Implantation in Mice
TLDR
It is found that injection of the uterine horn with CD28 antisense oligodeoxynucleotides leads to a decreased number of implantation sites, which suggest that CD28 participates in the process of embryo implantation in mice, which might play its role through delivering the second costimulatory signal.
Do circulating blood cells contribute to maternal tissue remodeling and embryo-maternal cross-talk around the implantation period?
  • H. Fujiwara
  • Biology, Medicine
    Molecular human reproduction
  • 2009
TLDR
It is suggested that circulating blood cells positively contribute to maternal tissue remodeling and embryo-maternal cross-talk around the implantation period in cooperation with the endocrine system.
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References

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