Splenic necrosis in mice infected with cytomegalovirus.

  title={Splenic necrosis in mice infected with cytomegalovirus.},
  author={Cedric A. Mims and Janine J. Gould},
  journal={The Journal of infectious diseases},
  volume={137 5},
Necrosis of the spleen is seen in mice of certain strains after injection of large doses of murine cytomegalovirus. Necrosis begins in perifollicular areas containing infected cells which do not appear to be macrophages, and in severe cases the entire spleen is involved. Necrosis is first visible three days after infection and is not prevented by treatment of mice with corticosteroids, cyclophosphamide, or theta antiserum. There is a striking loss of nucleated cells from the spleen at two to… CONTINUE READING

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