Splenic marginal zone lymphoma: characterization of 7q deletion and its value in diagnosis.

@article{Watkins2010SplenicMZ,
  title={Splenic marginal zone lymphoma: characterization of 7q deletion and its value in diagnosis.},
  author={Adam J Watkins and Yuanxue Huang and Hongtao Ye and Estelle Chanudet and Nicola F. Johnson and Rifat A. Hamoudi and Hongxiang Liu and Gehong Dong and Ayoma Deepthi Attygalle and Ellen D McPhail and Mark E. Law and Peter Gershon Isaacson and Laurence de Leval and Andrew Wotherspoon and Ming-Qing Du},
  journal={The Journal of pathology},
  year={2010},
  volume={220 4},
  pages={461-74}
}
The diagnosis of splenic marginal zone lymphoma (SMZL) is frequently a challenge, due to its lack of specific histological features and immunophenotypic markers, and the existence of other poorly characterized splenic lymphomas defying classification. Moreover, the clinical outcome of SMZL is variable, with 30% of cases pursuing an aggressive clinical course, the prediction of which remains problematic. Thus, there is a real need for biomarkers in the diagnosis and prognostication of SMZL. To… CONTINUE READING

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In SMZL , 7q32 deletion was inversely correlated with trisomy 18 , but not associated with other copy number changes , TP53 abnormalities , or IGH mutation status .
In SMZL , 7q32 deletion was inversely correlated with trisomy 18 , but not associated with other copy number changes , TP53 abnormalities , or IGH mutation status .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
The diagnosis of splenic marginal zone lymphoma ( SMZL ) is frequently a challenge , due to its lack of specific histological features and immunophenotypic markers , and the existence of other poorly characterized splenic lymphomas defying classification .
SpleenIs associated anatomic site ofSplenic Diseases
The diagnosis of splenic marginal zone lymphoma ( SMZL ) is frequently a challenge , due to its lack of specific histological features and immunophenotypic markers , and the existence of other poorly characterized splenic lymphomas defying classification .
SpleenIs primary anatomic site of diseaseSplenic Marginal Zone B-Cell Lymphoma
In conclusion , 7q32 deletion is a characteristic feature of SMZL , albeit seen in isolated cases of splenic B - cell lymphoma / leukaemia unclassifiable , and its detection may help the differential diagnosis of splenic B - cell lymphomas .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
The diagnosis of splenic marginal zone lymphoma ( SMZL ) is frequently a challenge , due to its lack of specific histological features and immunophenotypic markers , and the existence of other poorly characterized splenic lymphomas defying classification .
In conclusion , 7q32 deletion is a characteristic feature of SMZL , albeit seen in isolated cases of splenic B - cell lymphoma / leukaemia unclassifiable , and its detection may help the differential diagnosis of splenic B - cell lymphomas .
The diagnosis of splenic marginal zone lymphoma ( SMZL ) is frequently a challenge , due to its lack of specific histological features and immunophenotypic markers , and the existence of other poorly characterized splenic lymphomas defying classification .
The diagnosis of splenic marginal zone lymphoma ( SMZL ) is frequently a challenge , due to its lack of specific histological features and immunophenotypic markers , and the existence of other poorly characterized splenic lymphomas defying classification .
SpleenIs associated anatomic site ofSplenic Marginal Zone B-Cell Lymphoma
In conclusion , 7q32 deletion is a characteristic feature of SMZL , albeit seen in isolated cases of splenic B - cell lymphoma / leukaemia unclassifiable , and its detection may help the differential diagnosis of splenic B - cell lymphomas .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
The diagnosis of splenic marginal zone lymphoma ( SMZL ) is frequently a challenge , due to its lack of specific histological features and immunophenotypic markers , and the existence of other poorly characterized splenic lymphomas defying classification .
In conclusion , 7q32 deletion is a characteristic feature of SMZL , albeit seen in isolated cases of splenic B - cell lymphoma / leukaemia unclassifiable , and its detection may help the differential diagnosis of splenic B - cell lymphomas .
The diagnosis of splenic marginal zone lymphoma ( SMZL ) is frequently a challenge , due to its lack of specific histological features and immunophenotypic markers , and the existence of other poorly characterized splenic lymphomas defying classification .
The diagnosis of splenic marginal zone lymphoma ( SMZL ) is frequently a challenge , due to its lack of specific histological features and immunophenotypic markers , and the existence of other poorly characterized splenic lymphomas defying classification .
The diagnosis of splenic marginal zone lymphoma ( SMZL ) is frequently a challenge , due to its lack of specific histological features and immunophenotypic markers , and the existence of other poorly characterized splenic lymphomas defying classification .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
Although it is not yet possible to identify the genes targeted by the deletion , interphase FISH screening showed that the deletion was seen in SMZL ( 19/56 = 34% ) and splenic B - cell lymphoma / leukaemia unclassifiable ( 3/9 = 33% ) , but not in 39 cases of other splenic lymphomas including chronic lymphocytic leukaemia ( n = 14 ) , hairy cell leukaemia ( 4 ) , mantle cell lymphoma ( 12 ) , follicular lymphoma ( 6 ) , and others .
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