Splenic contraction-induced reversible increase in hemoglobin concentration in intermittent hypoxia.

  title={Splenic contraction-induced reversible increase in hemoglobin concentration in intermittent hypoxia.},
  author={Ichiro Kuwahira and Uguri Kamiya and Tamio Iwamoto and Y Moue and T. Urano and Yoshiyuki Ohta and Norberto C. Gonzalez},
  journal={Journal of applied physiology},
  volume={86 1},
The effect of intermittent hypoxia (IHx) on blood hemoglobin concentration ([Hb]) and the underlying mechanisms were studied in rats exposed to 10% O2, 1 h/day, for up to 5 wk. IHx protocols with longer daily hypoxic exposure show persistent polycythemia; however, it is unknown whether [Hb] increases transiently during hypoxia in protocols without polycythemia. Hypoxia produced a reversible [Hb] increase after 4 days of IHx but not in normoxic controls (NxC) or after shorter period of IHx… CONTINUE READING


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