Splenectomy protects the kidneys against ischemic reperfusion injury in the rat.

  title={Splenectomy protects the kidneys against ischemic reperfusion injury in the rat.},
  author={Toshiya Hiroyoshi and Masahiro Tsuchida and Koichi Uchiyama and Koki Fujikawa and Takahiro Komatsu and Yoshihiro Kanaoka and Hideyasu Matsuyama},
  journal={Transplant immunology},
  volume={27 1},
BACKGROUND Ischemic reperfusion (I/R) injury of the kidney is closely associated with delayed graft function, increased acute rejection, and late allograft dysfunction. Splenectomy reduced hepatic I/R injury by inhibiting leukocyte infiltration in the liver, release of TNF-α, cell apoptosis, and expression of caspase-3. Thus, we investigated the effects of splenectomy on renal I/R injury in the rat. METHODS Male Wistar rats were assigned to four groups: sham operation (sham group), sham… CONTINUE READING


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