Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis

@article{Huston2006SplenectomyIT,
  title={Splenectomy inactivates the cholinergic antiinflammatory pathway during lethal endotoxemia and polymicrobial sepsis},
  author={Jared M. Huston and Mahendar Ochani and Mauricio Rosas-Ballina and Hong Liao and Kanta Ochani and Valentin Pavlov and Margot Gallowitsch-Puerta and Mala Ashok and Christopher J. Czura and Brian M. J. Foxwell and Kevin J Tracey and L. Fernando Ulloa},
  journal={The Journal of Experimental Medicine},
  year={2006},
  volume={203},
  pages={1623 - 1628}
}
The innate immune system protects against infection and tissue injury through the specialized organs of the reticuloendothelial system, including the lungs, liver, and spleen. The central nervous system regulates innate immune responses via the vagus nerve, a mechanism termed the cholinergic antiinflammatory pathway. Vagus nerve stimulation inhibits proinflammatory cytokine production by signaling through the alpha7 nicotinic acetylcholine receptor subunit. Previously, the functional… CONTINUE READING
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