Splenda Alters Gut Microflora and Increases Intestinal P-Glycoprotein and Cytochrome P-450 in Male Rats

@article{Aboudonia2008SplendaAG,
  title={Splenda Alters Gut Microflora and Increases Intestinal P-Glycoprotein and Cytochrome P-450 in Male Rats},
  author={M. Abou-donia and E. El-Masry and A. Abdel-Rahman and R. McLendon and S. Schiffman},
  journal={Journal of Toxicology and Environmental Health, Part A},
  year={2008},
  volume={71},
  pages={1415 - 1429}
}
Splenda is comprised of the high-potency artificial sweetener sucralose (1.1%) and the fillers maltodextrin and glucose. Splenda was administered by oral gavage at 100, 300, 500, or 1000 mg/kg to male Sprague-Dawley rats for 12-wk, during which fecal samples were collected weekly for bacterial analysis and measurement of fecal pH. After 12-wk, half of the animals from each treatment group were sacrificed to determine the intestinal expression of the membrane efflux transporter P-glycoprotein (P… Expand
Intestinal Metabolism and Bioaccumulation of Sucralose In Adipose Tissue In The Rat
Expert panel report on a study of Splenda in male rats.
Sucralose, A Synthetic Organochlorine Sweetener: Overview of Biological Issues
  • S. Schiffman, K. Rother
  • Chemistry, Medicine
  • Journal of toxicology and environmental health. Part B, Critical reviews
  • 2013
Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice
  • S. M., P. M., +6 authors B. F.
  • Medicine
  • International journal of occupational and environmental health
  • 2016
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 79 REFERENCES
A carcinogenicity study of sucralose in the CD-1 mouse.
The role of intestinal bacteria in the metabolism of salicylazosulfapyridine.
The metabolic fate of sucralose in rats.
  • J. Sims, A. Roberts, J. Daniel, A. Renwick
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2000
Role of intestinal bacteria in nutrient metabolism.
Chlorpyrifos oxon interacts with the mammalian multidrug resistance protein, P-glycoprotein.
Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics.
The gut microbiota as an environmental factor that regulates fat storage.
  • F. Bäckhed, Hao Ding, +5 authors J. Gordon
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2004
Feeding resistant starch affects fecal and cecal microflora and short-chain fatty acids in rats.
Probiotics as modulators of the gut flora
...
1
2
3
4
5
...