Splenda Alters Gut Microflora and Increases Intestinal P-Glycoprotein and Cytochrome P-450 in Male Rats

  title={Splenda Alters Gut Microflora and Increases Intestinal P-Glycoprotein and Cytochrome P-450 in Male Rats},
  author={M. Abou-Donia and Eman M Elmasry and A. A. Abdel-Rahman and R. McLendon and S. Schiffman},
  journal={Journal of Toxicology and Environmental Health, Part A},
  pages={1415 - 1429}
  • M. Abou-Donia, Eman M Elmasry, +2 authors S. Schiffman
  • Published 2008
  • Biology, Medicine
  • Journal of Toxicology and Environmental Health, Part A
  • Splenda is comprised of the high-potency artificial sweetener sucralose (1.1%) and the fillers maltodextrin and glucose. Splenda was administered by oral gavage at 100, 300, 500, or 1000 mg/kg to male Sprague-Dawley rats for 12-wk, during which fecal samples were collected weekly for bacterial analysis and measurement of fecal pH. After 12-wk, half of the animals from each treatment group were sacrificed to determine the intestinal expression of the membrane efflux transporter P-glycoprotein (P… CONTINUE READING
    208 Citations

    Paper Mentions

    Interventional Clinical Trial
    Background: Artificial sweeteners like sucralose are found in many foods and drinks. Sucralose might affect hormones and cause health changes. Objective: To see if… Expand
    ConditionsHealthy Volunteers, Overweight
    Intestinal Metabolism and Bioaccumulation of Sucralose In Adipose Tissue In The Rat
    • 8
    Expert panel report on a study of Splenda in male rats.
    • 35
    • Highly Influenced
    • PDF
    Sucralose, A Synthetic Organochlorine Sweetener: Overview of Biological Issues
    • S. Schiffman, K. Rother
    • Chemistry, Medicine
    • Journal of toxicology and environmental health. Part B, Critical reviews
    • 2013
    • 91
    • PDF
    Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice
    • S. M., Padovani M, +6 authors B. F.
    • Medicine
    • International journal of occupational and environmental health
    • 2016
    • 16
    • PDF


    A carcinogenicity study of sucralose in the CD-1 mouse.
    • 33
    • Highly Influential
    The role of intestinal bacteria in the metabolism of salicylazosulfapyridine.
    • 373
    The metabolic fate of sucralose in rats.
    • J. Sims, A. Roberts, J. Daniel, A. Renwick
    • Chemistry, Medicine
    • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
    • 2000
    • 65
    • Highly Influential
    Role of intestinal bacteria in nutrient metabolism.
    • 368
    Chlorpyrifos oxon interacts with the mammalian multidrug resistance protein, P-glycoprotein.
    • 62
    • Highly Influential
    Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics.
    • 414
    The gut microbiota as an environmental factor that regulates fat storage.
    • F. Bäckhed, H. Ding, +5 authors J. Gordon
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences of the United States of America
    • 2004
    • 4,184
    • PDF
    Feeding resistant starch affects fecal and cecal microflora and short-chain fatty acids in rats.
    • 175
    • PDF
    Probiotics as modulators of the gut flora.
    • 465
    • PDF