Splenda Alters Gut Microflora and Increases Intestinal P-Glycoprotein and Cytochrome P-450 in Male Rats

@article{AbouDonia2008SplendaAG,
  title={Splenda Alters Gut Microflora and Increases Intestinal P-Glycoprotein and Cytochrome P-450 in Male Rats},
  author={Mohamed B. Abou‐Donia and Eman M. El-Masry and Ali A. Abdel-Rahman and Roger E. McLendon and Susan S. Schiffman},
  journal={Journal of Toxicology and Environmental Health, Part A},
  year={2008},
  volume={71},
  pages={1415 - 1429}
}
Splenda is comprised of the high-potency artificial sweetener sucralose (1.1%) and the fillers maltodextrin and glucose. Splenda was administered by oral gavage at 100, 300, 500, or 1000 mg/kg to male Sprague-Dawley rats for 12-wk, during which fecal samples were collected weekly for bacterial analysis and measurement of fecal pH. After 12-wk, half of the animals from each treatment group were sacrificed to determine the intestinal expression of the membrane efflux transporter P-glycoprotein (P… 

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