Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes.

@article{Ishida2006SpleenPA,
  title={Spleen plays an important role in the induction of accelerated blood clearance of PEGylated liposomes.},
  author={Tatsuhiro Ishida and Masako Ichihara and Xinyu Wang and Hiroshi Kiwada},
  journal={Journal of controlled release : official journal of the Controlled Release Society},
  year={2006},
  volume={115 3},
  pages={
          243-50
        }
}
  • T. Ishida, M. Ichihara, H. Kiwada
  • Published 27 October 2006
  • Biology, Medicine
  • Journal of controlled release : official journal of the Controlled Release Society
Induction of Cytochrome P450 Involved in the Accelerated Blood Clearance Phenomenon Induced by PEGylated Liposomes In Vivo
TLDR
P450 selective inhibitors confirmed the inhibition of hepatic CYP3A1 was accompanied by an attenuated magnitude of the ABC phenomenon, which strongly suggests that P450s may be induced by repeated injection of PEG-L, thus favoring metabolic clearance of the second dose.
PEG化ナノキャリア頻回投与によるaccelerated blood clearance現象の機構解明
TLDR
The data suggest that the initiation of ABC phenomenon would be size-dependent, and particles smaller than 30 nm did not induce ABC phenomenon, and the elucidation of the ABC phenomenon will be helpful for the development of DDS formulations.
Anti-PEG IgM elicited by injection of liposomes is involved in the enhanced blood clearance of a subsequent dose of PEGylated liposomes.
[Recent advances in the study of accelerated blood clearance phenomenon of PEGylated liposomes].
It is generally believed that liposomes modified with polyethylene glycol (PEG) have no or lower immunogenicity. However, based on many recent literatures, when the PEGylated liposomes were
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Injection of PEGylated liposomes in rats elicits PEG-specific IgM, which is responsible for rapid elimination of a second dose of PEGylated liposomes.
  • T. Ishida, M. Ichihara, H. Kiwada
  • Biology, Chemistry
    Journal of controlled release : official journal of the Controlled Release Society
  • 2006
Accelerated clearance of PEGylated liposomes in rats after repeated injections.
Factors affecting the accelerated blood clearance of polyethylene glycol-liposomes upon repeated injection.
TLDR
The results indicate that hepatosplenic macrophages play an essential role in the enhanced clearance effect and that the change in pharmacokinetic behavior upon repeated injection is a general characteristic of liposomes, unrelated to the presence of PEG.
Influence of the physicochemical properties of liposomes on the accelerated blood clearance phenomenon in rats.
Immunogenicity and Rapid Blood Clearance of Liposomes Containing Polyethylene Glycol-Lipid Conjugates and Nucleic Acid
TLDR
It is reported that liposome compositions containing PEG-lipid derivatives and encapsulated antisense oligodeoxynucleotide (ODN) or plasmid DNA elicit a strong immune response that results in the rapid blood clearance of subsequent doses in mice, sufficient to induce significant morbidity and, in some instances, mortality.
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