Spleen pigmentation in young C57BL mice is caused by accumulation of melanin.

@article{Heijden1995SpleenPI,
  title={Spleen pigmentation in young C57BL mice is caused by accumulation of melanin.},
  author={Adrian van der Heijden and Jaap E van Dijk and Arnoldina G. Lemmens and Anton Christian Beynen},
  journal={Laboratory animals},
  year={1995},
  volume={29 4},
  pages={459-63}
}
It has been previously reported that in 2 C57BL mouse sublines a dark pigmentation of the cranial part of the spleen occurs in up to 30% of the animals within the populations. It was not clear whether this discoloration is caused by melanosis, lipofuscinosis or haemosiderosis. With the use of light and electron microscopy of stained spleen sections, we identified the pigment in 14 out of 60 C57BL mice aged 8-10 wks. In the mice with pigmented spleens there was accumulation of melanin… CONTINUE READING