Splanchnic and renal metabolism of insulin in human subjects: a dose-response study.

@article{Ferrannini1983SplanchnicAR,
  title={Splanchnic and renal metabolism of insulin in human subjects: a dose-response study.},
  author={Ele Ferrannini and John Wahren and Ole K. Faber and Philip F. Felig and Chr. Binder and Ralph A DeFronzo},
  journal={The American journal of physiology},
  year={1983},
  volume={244 6},
  pages={E517-27}
}
Kinetic analyses of insulin metabolism were performed in 32 healthy subjects with hepatic-venous or renal-venous catheters, in whom steady-state conditions of hyperinsulinemia or hyperglycemia were achieved with the use of the glucose-insulin clamp technique. In the basal state, the splanchnic bed removed 42 +/- 2% of the insulin influx. After graded insulin infusions with maintenance of euglycemia, stable arterial insulin levels of 35-1,430 microU/ml were attained. Splanchnic insulin… CONTINUE READING

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