Spirotetronate Polyketides as Leads in Drug Discovery

  title={Spirotetronate Polyketides as Leads in Drug Discovery},
  author={Michelle H. Lacoske and Emmanuel A Theodorakis},
  booktitle={Journal of natural products},
The discovery of chlorothricin (1) defined a new family of microbial metabolites with potent antitumor antibiotic properties collectively referred to as spirotetronate polyketides. These microbial metabolites are structurally distinguished by the presence of a spirotetronate motif embedded within a macrocyclic core. Glycosylation at the periphery of this core contributes to the structural complexity and bioactivity of this motif. The spirotetronate family displays impressive chemical structures… CONTINUE READING