Spiroscytalin, a new tetramic acid and other metabolites of mixed biogenesis from Scytalidium cuboideum.

  title={Spiroscytalin, a new tetramic acid and other metabolites of mixed biogenesis from Scytalidium cuboideum.},
  author={Arlene A. Sy-Cordero and M. Figueroa and H. Raja and Maria Elena Meza Avi{\~n}a and Mitchell P Croatt and A. F. Adcock and D. Kroll and M. Wani and C. Pearce and N. Oberlies},
  volume={71 47},
  • Arlene A. Sy-Cordero, M. Figueroa, +7 authors N. Oberlies
  • Published 2015
  • Chemistry, Medicine
  • Tetrahedron
  • Spiroscytalin (1), a new tetramic acid that possesses an uncommon spiro-ring fusion between a polyketide-derived octalin ring system and a 2,4-pyrrolidinedione, along with two known compounds, leporin B (2) and purpactin A (3), were isolated from a solid phase culture of the fungus Scytalidium cuboideum (MSX 68345). The molecular connectivity of 1-3 was determined using NMR spectroscopy and mass spectrometry. The relative configurations of 1 and 2 were determined by NOESY experiments. The… CONTINUE READING
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