Spironolactone promotes autophagy via inhibiting PI3K/AKT/mTOR signalling pathway and reduce adhesive capacity damage in podocytes under mechanical stress

@inproceedings{Li2016SpironolactonePA,
  title={Spironolactone promotes autophagy via inhibiting PI3K/AKT/mTOR signalling pathway and reduce adhesive capacity damage in podocytes under mechanical stress},
  author={Dong Li and Zhenyu Lu and Zhongwei Xu and Junya Ji and Zhenfeng Zheng and Shan Lin and Tiekun Yan},
  booktitle={Bioscience reports},
  year={2016}
}
  • Dong Li, Zhenyu Lu, +4 authors Tiekun Yan
  • Published in Bioscience reports 2016
  • Medicine, Biology
  • Mechanical stress which would cause deleterious adhesive effects on podocytes is considered a major contributor to the early progress of diabetic nephropathy (DN). Our previous study has shown that spironolactone could ameliorate podocytic adhesive capacity in diabetic rats. Autophagy has been reported to have a protective role against renal injury. The present study investigated the underlying mechanisms by which spironolactone reduced adhesive capacity damage in podocytes under mechanical… CONTINUE READING

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