Spironolactone prevents diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats.

@article{Han2006SpironolactonePD,
  title={Spironolactone prevents diabetic nephropathy through an anti-inflammatory mechanism in type 2 diabetic rats.},
  author={Sang-Youb Han and Cy-Hyun Kim and Han-seong Kim and Yi-Hwa Jee and Hongjoo Song and Mihwa Lee and Kum-Hyun Han and Hyoung-Kyu Kim and Y. Kang and Jee Young Han and Y. Kim and Dr. Chang Yul Cha},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2006},
  volume={17 5},
  pages={1362-72}
}
Aldosterone induces myocardial fibrosis and vascular inflammation via proinflammatory and profibrotic cytokines. The effect of spironolactone on renal inflammation and renal function was investigated in type 2 diabetic rats. For define the molecular mechanism of spironolactone, the effect of spironolactone on the synthesis of monocyte chemotactic peptide-1 (MCP-1) and its upstream transcription factor, NF-kappaB, was evaluated in cultured mesangial cells and proximal tubular cells. There were… CONTINUE READING

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