Spironolactone inhibits the transcardiac extraction of aldosterone in patients with congestive heart failure.

Abstract

OBJECTIVES The study evaluated the transcardiac extraction or spillover of aldosterone (ALDO) in normal subjects and in patients with congestive heart failure (CHF). BACKGROUND Aldosterone promotes collagen synthesis and structural remodeling of target organs such as the heart. Spironolactone, an ALDO receptor antagonist, has recently been reported to… (More)

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Cite this paper

@article{Tsutamoto2000SpironolactoneIT, title={Spironolactone inhibits the transcardiac extraction of aldosterone in patients with congestive heart failure.}, author={Takayoshi Tsutamoto and Atsuyuki Wada and K. Maeda and Naoto Mabuchi and M. Hayashi and T. Tsutsui and M. Ohnishi and Motonari Sawaki and M. Fujii and Takumi Matsumoto and Hiromichi Horie and Y. Sugimoto and Minako Kinoshita}, journal={Journal of the American College of Cardiology}, year={2000}, volume={36 3}, pages={838-44} }