Spironolactone inhibits hyperglycemia-induced podocyte injury by attenuating ROS production.

Abstract

BACKGROUND Accumulating evidence suggests that mineralocorticoid receptor (MR) blockade effectively reduces proteinuria in diabetic nephropathy although the renin-angiotensin-aldosterone system is generally suppressed in diabetes. The present study was designed to confirm the antiproteinuric effect of MR blockade in diabetic rats and elucidate its mechanism… (More)
DOI: 10.1093/ndt/gfq750

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