Spironolactone-induced inhibition of aldosterone biosynthesis in primary aldosteronism: morphological and functional studies.


Twenty-five patients harboring aldosterone-producing adenomas were treated with spironolactone for 2-170 days immediately preoperatively. In the early period of administration of the drug (up to 27 days), plasma and urinary aldosterone decreased sharply while plasma renin activity (PRA) and serum potassium were rising. During this period of time… (More)

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