Spironolactone in type 2 diabetic nephropathy: Effects on proteinuria, blood pressure and renal function.

@article{Meiracker2006SpironolactoneIT,
  title={Spironolactone in type 2 diabetic nephropathy: Effects on proteinuria, blood pressure and renal function.},
  author={Anton H. van den Meiracker and Rini Ga Baggen and S Pauli and Anouk Lindemans and Arnold G. Vulto and Don Poldermans and Frans Boomsma},
  journal={Journal of hypertension},
  year={2006},
  volume={24 11},
  pages={
          2285-92
        }
}
OBJECTIVE To study the effects of addition of spironolactone to angiotensin-converting enzyme (ACE) inhibition or angiotensin II (AngII) receptor antagonism on proteinuria, blood pressure (BP) and renal function in overt type 2 diabetic nephropathy. DESIGN A placebo-controlled, double-blind, parallel-group trial in patients from two outpatient clinics with a follow-up of 1 year. METHODS Type 2 diabetic patients with macroalbuminuria, despite long-term use of an ACE inhibitor or AngII… CONTINUE READING

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