Spironolactone exhibits direct renoprotective effects and inhibits renal renin-angiotensin-aldosterone system in diabetic rats.

@article{Taira2008SpironolactoneED,
  title={Spironolactone exhibits direct renoprotective effects and inhibits renal renin-angiotensin-aldosterone system in diabetic rats.},
  author={Masateru Taira and Hiroe Toba and Masafumi Murakami and Ikumi Iga and Ryoko Serizawa and Shoko Murata and Miyuki Kobara and Tetsuo Nakata},
  journal={European journal of pharmacology},
  year={2008},
  volume={589 1-3},
  pages={264-71}
}
Aldosterone itself has been reported to participate in mediating renal injury, and it was confirmed that the aldosterone synthase CYP11B2 gene, protein, and aldosterone production are locally present in the kidney. To test the hypothesis that a mineralocorticoid receptor antagonist might ameliorate diabetic nephropathy and the inhibition of renal CYP11B2 expression might be associated with these renoprotective effects, spironolactone (50 mg/kg/day) was administered by gavage to… CONTINUE READING
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