Spironolactone and dimethylsulfoxide effect on glucose metabolism and oxidative stress markers in polycystic ovarian syndrome rat model.

@article{Daneasa2014SpironolactoneAD,
  title={Spironolactone and dimethylsulfoxide effect on glucose metabolism and oxidative stress markers in polycystic ovarian syndrome rat model.},
  author={Alexandra Ioana Daneasa and Cristina Cucolaş and M Furcea and Pompei Bolfa and Sorin Marian Dudea and Diana Olteanu and Marius Costel Alupei and Adriana Mureşan and Gabriela Adriana Filip},
  journal={Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association},
  year={2014},
  volume={122 3},
  pages={
          154-62
        }
}
Because polycystic ovarian syndrome (PCOS) is a risk factor for type 2 diabetes, the affected women can present frequently prediabetic states such as impaired fasting glycaemia and/or impaired glucose tolerance. The purpose of our study is to explore the effect of antiandrogenic spironolactone on glucose metabolism and oxidative stress (OS) parameters in oestradiol valerate (OV) induced PCOS rat model.72 female Wistar rats were distributed either to PCOS group (n=65, OV dissolved in sesame oil… CONTINUE READING