Spironolactone ameliorates renal injury and connective tissue growth factor expression in type II diabetic rats.

Abstract

Administration of spironolactone provides a beneficial effect in various animal models of renal injury. In this study, we investigated whether spironolactone prevents the progression of diabetic nephropathy through reduction of connective tissue growth factor (CTGF) synthesis in type II diabetic rats. In addition, we evaluated the effect of aldosterone and… (More)

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