Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice.

  title={Spironolactone ameliorates PIT1-dependent vascular osteoinduction in klotho-hypomorphic mice.},
  author={Jakob G. J. Voelkl and Ioana S Alesutan and Christina B. Leibrock and Leticia Quintanilla-Martinez and Volker Kuhn and Martina Feger and S. M. Shahjahan Mia and Mohamed Siyabeldin E. Ahmed and Kevin P. Rosenblatt and Makoto Kuro-O and Florian Lang},
  journal={The Journal of clinical investigation},
  volume={123 2},
Klotho is a potent regulator of 1,25-hydroxyvitamin D3 [1,25(OH)2D3] formation and calcium-phosphate metabolism. Klotho-hypomorphic mice (kl/kl mice) suffer from severe growth deficits, rapid aging, hyperphosphatemia, hyperaldosteronism, and extensive vascular and soft tissue calcification. Sequelae of klotho deficiency are similar to those of end-stage renal disease. We show here that the mineralocorticoid receptor antagonist spironolactone reduced vascular and soft tissue calcification and… CONTINUE READING


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