Spironolactone‐induced hepatitis

  title={Spironolactone‐induced hepatitis},
  author={K E Thai and Rodney Daniel Sinclair},
  journal={Australasian Journal of Dermatology},
There is widespread use of spironolactone in medical practice and the indications for its use well established and side effect profile well known. Herein, we present a case of drug‐induced hepatitis occurring in a 50‐year‐old woman using spironolactone for the treatment of androgenetic alopecia. Six weeks after commencement of spironolactone the patient became unwell, complained of an extensive itch, but no icterus or jaundice. Liver function tests found abnormally elevated bilirubin and… Expand
Innovative use of spironolactone as an antiandrogen in the treatment of female pattern hair loss.
Satisfactory treatment response to antiandrogen therapy supports the involvement of androgens in the pathogenesis of female pattern hair loss and spironolactone has been used off-label in FPHL for over 20 years. Expand
Early onset hepatotoxicity associated with low dose fluconazole therapy in a critically ill patient
Low dose fluconazole may induce early onset of hepatotoxicity in critically ill patient with kidney failure, and prompt discontinuation of flu Conazole therapy is needed to prevent further deterioration in liver function. Expand
Hormonal therapies in acne
  • J. C. Shaw
  • Medicine
  • Expert opinion on pharmacotherapy
  • 2002
The physiological basis for hormonal influence in acne is covered, the treatments that are in use today and those that show promise for the future are discussed. Expand
Drug induced liver disease
Drug-induced liver disease can result from dosage-dependent hepatotoxicity or from adverse reactions to drugs used in therapeutic dosage, so that drugs must be considered as the possible causal agent for all unexplained cases of liver disease. Expand
Antiandrogen therapy for androgenetic alopecia
While these agents are highly effective at preventing hair loss and most patients experience some regrowth, few patients experience dramatic hair regrowth. Expand
Female pattern hair loss: a pilot study investigating combination therapy with low‐dose oral minoxidil and spironolactone
  • R. Sinclair
  • Medicine
  • International journal of dermatology
  • 2018
Minoxidil and spironolactone are oral antihypertensives known to stimulate hair growth and may be useful in combination with other drugs to reduce the risk of hair loss. Expand
Female pattern alopecia: current perspectives
Current perspectives on therapeutic options for female pattern hair loss are reviewed, with the aim of therapy being to slow or stop disease progression with contentment despite patient expectations of permanent hair regrowth. Expand
Disorders of Hair


Simultaneous liver and lung toxicity related to the nonsteroidal antiandrogen nilutamide (Anandron): a case report.
A 69-year-old patient treated for stage C adenocarcinoma of the prostate with the combination of the luteinizing hormone-releasing hormone agonist and the antiandrogen nilutamide who developed simultaneous liver and lung toxicity is reported. Expand
Liver damage induced by coumarin anticoagulants.
Although liver damage induced by coumarin derivates is rare, it is important to be aware of the hepatotoxic potential of these drugs, which, in most cases, mimics the clinical presentation of viral hepatitis. Expand
Spironolactone hepatitis in primary hyperaldosteronism.
Excerpt Spironolactone, a 17-spirolactone that competitively inhibits aldosterone, is used in treating secondary hyperaldosteronism (1) and is the preferred drug in treating primary hyperaldosteron...
Incidence of liver toxicity associated with the use of flutamide in prostate cancer patients.
The cases reported so far indicate that the incidence of flutamide-induced liver toxicity is very low, and serial blood aminotransferase measurements are recommended at 2 and 4 weeks of treatment in order to detect early signs of possible flutamia-induced hepatic injury, thus avoiding the low potential risk of clinically significant liver toxicity. Expand
Frequency of flutamide induced hepatotoxicity in patients with prostate carcinoma
The observed severe hepatotoxicity in two patients who received flutamide therapy for prostate cancer occurred more frequent than is predicted in the literature and should be taken off therapy as soon as possible. Expand
Antiandrogen Hepatotoxicity in Patients with Chronic Viral Hepatitis
It is suggested that patients with chronic viral hepatitis probably are at a higher risk of developing antiandrogen hepatotoxicity and close monitoring of liver functions in patients with Chronic viral hepatitis is advised if anti androgen therapy is necessary. Expand
[Chronic hepatitis].
  • R. Figueroa Barrios
  • Medicine
  • Revista de gastroenterologia del Peru : organo oficial de la Sociedad de Gastroenterologia del Peru
  • 1995
Antiviral treatment of chronic hepatitis B and C with interpheron alfa is employed, controlling symptoms and abnormal biochemistry and the progression to cirrhosis and liver cancer in 30 to 40% patients. Expand
The general opinion of the value of diuretics as a class of therapeutic agents does not stand high?firstly, because it is not sufficiently appreciated that these drugs constitute a purely empiricalExpand
Basic and Clinical Pharmacology
This book succeeds Review of Medical Pharmacology, by Meyers, Jawetz, and Goldfien, and deals with relevant information regarding the clinical use of drugs on the various battlefields. Expand
MIMS Australia . Diuretics
  • MIMS Annual , 24 th edn
  • 2000