Spirometry performed as part of the Manchester community-based lung cancer screening programme detects a high prevalence of airflow obstruction in individuals without a prior diagnosis of COPD

@article{Balata2020SpirometryPA,
  title={Spirometry performed as part of the Manchester community-based lung cancer screening programme detects a high prevalence of airflow obstruction in individuals without a prior diagnosis of COPD},
  author={Haval Balata and Jonathan Harvey and Philip V. Barber and Denis Colligan and Rebecca Duerden and Peter J Elton and Matthew Evison and Melanie Greaves and John Howells and Klaus Loureiro Irion and Devinda Karunaratne and Stuart Mellor and Tom D. Newton and R Sawyer and Anna Sharman and Elaine Smith and Ben Taylor and Sarah Taylor and Janet Tonge and Anna Walsham and James Whittaker and Joergen Vestbo and Richard C. Booton and Phil A Crosbie},
  journal={Thorax},
  year={2020},
  volume={75},
  pages={655 - 660}
}
Background COPD is a major cause of morbidity and mortality in populations eligible for lung cancer screening. We investigated the role of spirometry in a community-based lung cancer screening programme. Methods Ever smokers, age 55–74, resident in three deprived areas of Manchester were invited to a ‘Lung Health Check’ (LHC) based in convenient community locations. Spirometry was incorporated into the LHCs alongside lung cancer risk estimation (Prostate, Lung, Colorectal and Ovarian Study Risk… 

Detection of COPD in the SUMMIT Study Lung Cancer Screening Cohort using Symptoms and Spirometry.

TLDR
Targeted case-finding within LCS detects high rates of undiagnosed symptomatic COPD in those most at risk of lung cancer, and combines symptom assessment with spirometry to enable earlier diagnosis of clinically significant COPD and facilitate increased understanding of lungcancer risk in COPD.

Implications of incidental findings from lung screening for primary care: data from a UK pilot

TLDR
LHCs result in a small increase to primary care workload provided a strict referral protocol is adhered to, and changes to patient management arising from incidental findings referrals are infrequent.

Impact of Chronic Obstructive Pulmonary Disease on the Mortality of Patients with Small Cell Lung Cancer

TLDR
A diagnosis of COPD was associated with reduced 1- year mortality in SCLC patients, but no significant difference after 1-year in this population of patients.

Chronic Obstructive Pulmonary Disease and Lung Cancer: A Review for Clinicians.

TLDR
This manuscript succinctly reviews the epidemiology and common pathogenetic factors for the concurrence of COPD and LC, and summarizes the indications, benefits, and complications of LC screening in patients with COPD, and the assessment of risk factors for patientswith COPD undergoing consideration of various treatment options for LC.

Feasibility and acceptability of a community pharmacy referral service for suspected lung cancer symptoms

TLDR
A community pharmacy referral service for lung symptoms was considered an acceptable alternative pathway to symptomatic diagnosis of lung cancer in deprived communities and would require workforce capacity and training to be addressed to ensure optimum utilisation and promotion of the service.

The prevalence of comorbidity in the lung cancer screening population: A systematic review and meta-analysis.

TLDR
Comorbidities were highly prevalent in LCS populations and likely to be more prevalent than in other cancer screening programmes and further research on the burden of comorbid disease and its impact on screening uptake and outcomes is needed.

Survival impact of treatment for chronic obstructive pulmonary disease in patients with advanced non-small-cell lung cancer

TLDR
COPD had a significant association with poor prognosis in advanced NSCLC patients if they did not have pharmacological treatment for COPD, and treatment for coexisting COPD has the potential to salvage the prognosis.

COPD_A_328938 3255..3262

TLDR
A diagnosis of COPD was associated with reduced 1- year mortality in SCLC patients, but no significant difference after 1-year in this population of patients.

References

SHOWING 1-10 OF 36 REFERENCES

Implementing lung cancer screening: baseline results from a community-based ‘Lung Health Check’ pilot in deprived areas of Manchester

TLDR
Taking lung cancer screening into communities, with an LHC approach, is effective and engages populations in deprived areas.

Identification of chronic obstructive pulmonary disease in lung cancer screening computed tomographic scans.

TLDR
Among men who are current and former heavy smokers, low-dose inspiratory and expiratory CT scans obtained for lung cancer screening can identify participants with COPD, with a sensitivity of 63% and a specificity of 88%.

COPD prevalence is increased in lung cancer, independent of age, sex and smoking history

TLDR
The prevalence of COPD in newly diagnosed lung cancer cases was six-fold greater than in matched smokers; this is much greater than previously reported.

Determinants of underdiagnosis of COPD in national and international surveys.

TLDR
Even with substantial heterogeneity in COPD prevalence, COPD underdiagnosis is universally high and effective management strategies are available for COPD, so spirometry can help in the diagnosis of COPD at a stage when treatment will lead to better outcomes and improved quality of life.

Barriers to uptake among high-risk individuals declining participation in lung cancer screening: a mixed methods analysis of the UK Lung Cancer Screening (UKLS) trial

TLDR
A profile of risk factors for non-participation in lung screening has emerged, with underlying reasons largely relating to practical and emotional barriers.

Prevalence, severity and underdiagnosis of COPD in the primary care setting

TLDR
The prevalence and underdiagnosis of COPD in adult patients in this primary care setting made case finding worthwhile, and large numbers of newly detected patients were symptomatic and needed treatment.

Impact of low-dose CT screening on smoking cessation among high-risk participants in the UK Lung Cancer Screening Trial

TLDR
CT lung cancer screening for high-risk participants presents a teachable moment for smoking cessation, especially among those who receive a positive scan result and those receiving a negative result.