Spiroindolones, a potent compound class for the treatment of malaria.

@article{Rottmann2010SpiroindolonesAP,
  title={Spiroindolones, a potent compound class for the treatment of malaria.},
  author={Matthias Rottmann and Case McNamara and Bryan K. S. Yeung and Marcus C S Lee and Bin Zou and Bruce Russell and Patrick Seitz and David M. Plouffe and Neekesh V. Dharia and Jocelyn Tan and Steven Bruce Cohen and Kathryn S.R. Spencer and G. Gonz{\'a}lez-P{\'a}ez and Suresh B. Lakshminarayana and Anne Goh and Rossarin Suwanarusk and Timothy J. Jegla and Esther Katharina Schmitt and Hans-Peter Beck and Reto Brun and Francois Nosten and Laurent R{\'e}nia and V{\'e}ronique Dartois and Thomas H. Keller and David A. Fidock and Elizabeth A. Winzeler and Thierry Tidiane Diagana},
  journal={Science},
  year={2010},
  volume={329 5996},
  pages={
          1175-80
        }
}
Recent reports of increased tolerance to artemisinin derivatives--the most recently adopted class of antimalarials--have prompted a need for new treatments. The spirotetrahydro-beta-carbolines, or spiroindolones, are potent drugs that kill the blood stages of Plasmodium falciparum and Plasmodium vivax clinical isolates at low nanomolar concentration. Spiroindolones rapidly inhibit protein synthesis in P. falciparum, an effect that is ablated in parasites bearing nonsynonymous mutations in the… CONTINUE READING

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