Spirocurcasone, a diterpenoid with a novel carbon skeleton from Jatropha curcas.

  title={Spirocurcasone, a diterpenoid with a novel carbon skeleton from Jatropha curcas.},
  author={Giuseppina Chianese and Ernesto Fattorusso and Olapeju O. Aiyelaagbe and Paolo Luciano and Heinz C. Schröder and Werner E. G. M{\"u}ller and Orazio Taglialatela‐Scafati},
  journal={Organic letters},
  volume={13 2},
Spirocurcasone (14), a diterpenoid possessing the unprecedented "spirorhamnofolane" skeleton, was isolated from the root barks of Jatropha curcas, a plant extensively cultivated throughout the world, along with 11 known and two other new diterpenoids. The stereostructure of spirocurcasone was established using HRESIMS, NMR, and quantum mechanical calculation of the electronic circular dichroic (ECD) spectrum. Some of the isolated diterpenoids showed a potent activity against L5178Y, a mouse… 
Jatrocurcadiones A and B: two novel diterpenoids with an unusual 10,11-seco-premyrsinane skeleton from Jatropha curcas
Two novel diterpenoids, jatrocurcadiones A (1) and B (2), possessing an unusual 10,11-seco-premyrsinane skeleton were isolated from the twigs of Jatropha curcas. Their structures were determined by
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Two novel tricyclic spirolactones bearing long linear alkyl chains, yaoshanenolides A (1) and B (2), formed by Diels-Alder[4 + 2] cycloaddition of a molecule of each butenolide with β-phellandrene,
Dimericursones A and B: two unprecedented hexacyclic dimeric diterpenoids from the root barks of Jatropha curcas.
Dimericursones A and B, two unprecedented hexacyclic dimeric diterpenoids, were obtained from the root barks of Jatropha curcas and showed significant inhibition on nitric oxide production of lipopolysaccharide-induced RAW264.
New terpenoids from the roots of Jatropha curcas
Two new sesquiterpenoids, (1S,2R)-dihydroxycycloax-4(15)-ene, 14- dehydroxyl daucucarotol, and one new rhamnofalane diterpenoid, 2-hydroxy-3-dehydroxycaniojane, together with two known compounds, were isolated from the roots of Jatropha curcas.
One-step semisynthesis method of spirocurcasone and pyracurcasone from curcusones A and B.
The plausible mechanism of the formation of pyracurcasone was proposed, and the proposed biogenetic origin for spirocurcasone by Taglialatela-Scafati was confirmed.