Spiradenocylindroma of the kidney: clinical and genetic findings suggesting a role of somatic mutation of the CYLD1 gene in the oncogenesis of an unusual renal neoplasm.

@article{Stroebel2002SpiradenocylindromaOT,
  title={Spiradenocylindroma of the kidney: clinical and genetic findings suggesting a role of somatic mutation of the CYLD1 gene in the oncogenesis of an unusual renal neoplasm.},
  author={Philipp Stroebel and Andreas Zettl and Zhou Ren and Petr Starostik and Hubertus Riedmiller and Stephan Stoerkel and Hans-Konrad Mueller-Hermelink and Alexander Marx},
  journal={The American journal of surgical pathology},
  year={2002},
  volume={26 1},
  pages={119-24}
}
We describe the morphology and comparative genomic hybridization findings in a tumor for which we propose the term "spiradenocylindroma" of the kidney. The tumor arose in the wall of a renal cyst in an otherwise healthy male patient who had a favorable clinical course after nephrectomy. Tumor cells formed either large nodules exhibiting a solid or trabecular architecture with conspicuous perivascular spaces or cylindromatous small tumor cell islands arranged in a jigsaw pattern. Focally, there… CONTINUE READING

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