Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch

  title={Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch},
  author={D. Andrew and A. Craig},
  journal={Nature Neuroscience},
  • D. Andrew, A. Craig
  • Published 2001
  • Chemistry, Medicine
  • Nature Neuroscience
  • We found a class of lamina I spinothalamic tract (STT) neurons selectively excited by iontophoretic histamine. The responses of this class of neurons parallel the pure itching sensation this stimulus elicits in humans, and match the responses of peripheral C-fibers that have similar selectivity. These neurons have distinct central conduction velocities and thalamic projections, indicating that they constitute a unique subset of STT neurons. These findings can explain why a lesion of the lateral… CONTINUE READING
    492 Citations
    Physiological properties of the lamina I spinoparabrachial neurons in the mouse
    • J. Allard
    • Medicine, Chemistry
    • The Journal of physiology
    • 2019
    • 3
    Updated neurophysiology of itch.
    • A. Ikoma
    • Medicine
    • Biological & pharmaceutical bulletin
    • 2013
    • 23
    A labeled-line for cold from the periphery to the parabrachial nucleus
    • PDF
    Pruriceptive spinothalamic tract neurons: physiological properties and projection targets in the primate.
    • 100
    • PDF
    Is there a specific lamina I spinothalamocortical pathway for pain and temperature sensations in primates?
    • A. Craig, A. Blomqvist
    • Medicine
    • The journal of pain : official journal of the American Pain Society
    • 2002
    • 50
    Spinothalamic lamina I neurones selectively responsive to cutaneous warming in cats
    • 102
    Peripheral and Central Mechanisms of Itch
    • 87
    A tale of two neurons in the upper airways: Pain versus itch
    • 12


    Nociceptive and thermoreceptive lamina I neurons are anatomically distinct
    • 247
    Itching for an explanation
    • 156
    Response to an itch-producing substance in cat. I. Cutaneous receptor populations with myelinated axons
    • 72
    Discharge patterns of human C-fibers induced by itching and burning stimuli.
    • 200