Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch

@article{Andrew2001SpinothalamicLI,
  title={Spinothalamic lamina I neurons selectively sensitive to histamine: a central neural pathway for itch},
  author={D. Andrew and A. Craig},
  journal={Nature Neuroscience},
  year={2001},
  volume={4},
  pages={72-77}
}
  • D. Andrew, A. Craig
  • Published 2001
  • Chemistry, Medicine
  • Nature Neuroscience
  • We found a class of lamina I spinothalamic tract (STT) neurons selectively excited by iontophoretic histamine. The responses of this class of neurons parallel the pure itching sensation this stimulus elicits in humans, and match the responses of peripheral C-fibers that have similar selectivity. These neurons have distinct central conduction velocities and thalamic projections, indicating that they constitute a unique subset of STT neurons. These findings can explain why a lesion of the lateral… CONTINUE READING
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