Spinophilin stabilizes cell surface expression of alpha 2B-adrenergic receptors.

@article{Brady2003SpinophilinSC,
  title={Spinophilin stabilizes cell surface expression of alpha 2B-adrenergic receptors.},
  author={Ashley E. Brady and Qin Wang and Roger J Colbran and P B Allen and Paul Greengard and Lee E. Limbird},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 34},
  pages={
          32405-12
        }
}
The third intracellular (3i) loops of the alpha 2A- and alpha 2B-adrenergic receptor (AR) subtypes are critical for retention of these receptors at the basolateral surface of polarized Madin-Darby canine kidney (MDCKII) cells at steady state. The third intracellular loops of the alpha 2A, alpha 2B, and alpha 2C-AR subtypes interact with spinophilin, a multidomain protein that, like the three alpha 2-AR subtypes, is enriched at the basolateral surface of MDCKII cells. The present studies provide… CONTINUE READING

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