Spinophilin inhibits the binding of RGS8 to M1-mAChR but enhances the regulatory function of RGS8.


We showed previously that RGS8 directly binds to the third intracellular loop (i3L) of the M1 muscarinic acetylcholine receptor using the sequence MPRR at the N-terminus of RGS8 and specifically inhibits signal transduction. Here, we identified spinophilin (SPL) as an RGS8-interacting protein. We found that the SPL-binding site of RGS8 is the MPRR sequence… (More)
DOI: 10.1016/j.bbrc.2008.09.096


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